Ejogo is the daughter of Elizabeth, a Scottish tour guide, and Charles Ejogo, an Igbo entrepreneur.
Ejogo's television career began in the UK in the early 1990s, where she presented the children's series Saturday Disney. Subsequently, she has had an acting career in the US. She has appeared in Metro with Eddie Murphy, What's the Worst That Could Happen? with Martin Lawrence, and Love's Labour's Lost with Kenneth Branagh, among other films, and also presented The Carmen Ejogo Video Show — her own video show on BSB's Power Station channel.
She starred as Thomas Jefferson's slave mistress in the television drama Sally Hemmings: An American Scandal.
Sally Hemmings: An American Scandal
What's the Worst That Could Happen? (Special Edition)